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SiLEncing SLE: the power and promise of small noncoding RNAs

Date

Authors

Rigby, Robert

Garcia De Vinuesa, Maria Carola

Publisher

Lippincott Williams & Wilkins

Abstract

Dysregulation of the RNA silencing machinery has been implicated in systemic lupus erythematosus pathogenesis. Although microRNA profiling may prove to be a useful diagnostic and prognostic tool for a notoriously heterogeneous disease, manipulation of RNA interference emerges as a powerful and potentially specific means to correct dysregulated gene expression in systemic lupus erythematosus patients.

Keywords

Keywords: autoantibody; B cell activating factor receptor; BIM protein; cell protein; dicer; double stranded RNA; immunosuppressive agent; interleukin 21; liposome; messenger RNA; microRNA; phosphatase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; RNA in Micro RNA; Roquin; Small interfering RNA; Small noncoding RNA; Systemic lupus erythematosus

URI

http://hdl.handle.net/1885/30622

Collections

ANU Research Publications

Source

Current Opinion in Rheumatology

Type

Journal article

DOI

10.1097/BOR.0b013e328304b45e

Restricted until

2037-12-31

Downloads

File

Description

01_Rigby_SiLEncing_SLE:_the_power_and_2008.pdf (305.17 KB)