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Not always an innocent bystander: the impact of stabilised phosphopantetheine moieties when studying nonribosomal peptide biosynthesis

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Date

2023

Authors

Ho, Yee Ting Candace
Kaczmarski, Joe Alexander
Tailhades, Julien
Izore, Thierry
Steer, David L.
Schittenhelm, Ralf B
Tosin, Manuela
Jackson, Colin
Cryle, Max

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry

Abstract

Nonribosomal peptide synthetases produce many important peptide natural products and are centred around carrier proteins (CPs) that deliver intermediates to various catalytic domains. We show that the replacement of CP substrate thioesters by stabilised ester analogues leads to active condensation domain complexes, whereas amide stabilisation generates non-functional complexes.

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Citation

URI

https://hdl.handle.net/1885/733715044

Collections

ANU Research Publications

Source

Chemical Communications

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1039/d3cc01578e

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d3cc01578e.pdf (826.38 KB)

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