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Cholinergic inhibition of neocortical pyramidal neurons

Date

Authors

Gulledge, Allan T

Stuart, Gregory J

Publisher

Society for Neuroscience

Abstract

Acetylcholine (ACh) is a central neurotransmitter critical for normal cognitive function. Here we show that transient muscarinic acetylcholine receptor activation directly inhibits neocortical layer 5 pyramidal neurons. Using whole-cell and cell-attached

Keywords

Keywords: 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide; 4 aminobutyric acid receptor blocking agent; acetylcholine; atropine; benzyl[3 [[1 (3,4 dichlorophenyl)ethyl]amino] 2 hydroxypropyl]phosphinic acid; cadmium; calcium; calcium chelating a Acetylcholine; Calcium imaging; Muscarinic receptor; Neocortex; Pyramidal neuron; SK channel

URI

http://hdl.handle.net/1885/79899

Collections

ANU Research Publications

Source

Journal of Neuroscience

Type

Journal article

DOI

10.1523/JNEUROSCI.2697-05.2005

Restricted until

2037-12-31

Downloads

File

Description

01_Gulledge_Cholinergic_inhibition_of_2005.pdf (980.34 KB)

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