Fabrication and cyto-compatibility of Fe3O4/SiO2/graphene-CdTeQDs/CS nanocomposites for drug delivery

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dc.contributor.authorOu, Jun
dc.contributor.authorWang, Fang
dc.contributor.authorHuang, Yuanjie
dc.contributor.authorLi, Duosheng
dc.contributor.authorJiang, Yuming
dc.contributor.authorQin, Qing Hua
dc.contributor.authorStachurski, Zbigniew
dc.contributor.authorTricoli, Antonio
dc.contributor.authorZhang, Tina (Meng)
dc.date.accessioned2015-12-08T22:20:22Z
dc.date.issued2014
dc.date.updated2015-12-08T08:29:58Z
dc.description.abstractSynthesis of magnetic Fe3O4/SiO2/graphene-CdTe QDs/chitosan nanocomposites (FGQCs) is investigated with respect to their potential of improving the drug loading content above that of magnetic/fluorescent bifunctional nanocomposites. To evaluate the performance of the FGQCs, their surface morphology was thoroughly assessed. The in vitro interaction between the FGQCs and heptoma cell line smmc-7721 cells was observed for the first time by TEM ultrathin section imaging. At an excitation wavelength of 365nm, the graphene-QDs exhibit a strong luminescence in aqueous environments. The loading content and entrapment efficiency of the FGQCs were 70% and 50%, respectively. The cytotoxicity of this novel drug delivery system was evaluated in vitro using heptoma cell line smmc-7721 and quantified by the 3-(4,5-dimethylthiazol-z-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results show that FGQCs are a promising new multifunctional material for drug delivery in biological and medical applications.
dc.identifier.issn0927-7765
dc.identifier.urihttp://hdl.handle.net/1885/31960
dc.publisherElsevier
dc.sourceColloids and Surfaces B: Biointerfaces
dc.titleFabrication and cyto-compatibility of Fe3O4/SiO2/graphene-CdTeQDs/CS nanocomposites for drug delivery
dc.typeJournal article
local.bibliographicCitation.lastpage472
local.bibliographicCitation.startpage466
local.contributor.affiliationOu, Jun, Guilin University of Technology
local.contributor.affiliationWang, Fang, Guilin University of Technology
local.contributor.affiliationHuang, Yuanjie, Guangxi Medical University
local.contributor.affiliationLi, Duosheng, Materials Science and Engineering College,
local.contributor.affiliationJiang, Yuming, Guilin University of Technology
local.contributor.affiliationQin, Qing Hua, College of Engineering and Computer Science, ANU
local.contributor.affiliationStachurski, Zbigniew, College of Engineering and Computer Science, ANU
local.contributor.affiliationTricoli, Antonio, College of Engineering and Computer Science, ANU
local.contributor.affiliationZhang, Tina (Meng), College of Engineering and Computer Science, ANU
local.contributor.authoruidQin, Qing Hua, u4119044
local.contributor.authoruidStachurski, Zbigniew, u9300839
local.contributor.authoruidTricoli, Antonio, u5276175
local.contributor.authoruidZhang, Tina (Meng), u4161586
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor091200 - MATERIALS ENGINEERING
local.identifier.absseo970109 - Expanding Knowledge in Engineering
local.identifier.ariespublicationu5114172xPUB87
local.identifier.citationvolume117
local.identifier.doi10.1016/j.colsurfb.2013.12.003
local.identifier.scopusID2-s2.0-84899618832
local.identifier.thomsonID000336018700061
local.type.statusPublished Version

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