Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha
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Fontes, Marcos
Teh, Trazel
Jans, David A
Brinkworth, Ross I
Kobe, Bostjan
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American Society for Biochemistry and Molecular Biology Inc
Abstract
Importin-α is the nuclear import receptor that recognizes cargo proteins carrying conventional basic monopartite and bipartite nuclear localization sequences (NLSs) and facilitates their transport into the nucleus. Bipartite NLSs contain two clusters of
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Journal of Biological Chemistry