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Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha

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Date

2003

Authors

Fontes, Marcos
Teh, Trazel
Jans, David A
Brinkworth, Ross I
Kobe, Bostjan

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

Importin-α is the nuclear import receptor that recognizes cargo proteins carrying conventional basic monopartite and bipartite nuclear localization sequences (NLSs) and facilitates their transport into the nucleus. Bipartite NLSs contain two clusters of

Description

Keywords

Keywords: Conformations; Crystallization; Proteins; Nuclear localization sequences (NLS); Biochemistry; karyopherin alpha; phosphoprotein; phosphoprotein n1n2; retinoblastoma protein; unclassified drug; article; binding affinity; cell nucleus; crystallization; huma

Citation

URI

http://hdl.handle.net/1885/75342

Collections

ANU Research Publications

Source

Journal of Biological Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1074/jbc.M303275200

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