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A chemoenzymatic total synthesis of ent -narciclasine

Date

Authors

Matveenko, Maria

Banwell, Martin

Willis, Anthony

Publisher

Elsevier

Abstract

The synthesis of the title compound [(-)-1] has been achieved, for the first time, by reacting the aryl boronic acid ester 4 with the aminoconduritol derivative 6 under Suzuki-Miyaura cross-coupling conditions then subjecting the product phenanthridinone

Keywords

Keywords: benzene derivative; boronic acid derivative; bromide; isoenzyme; narciclasine; phenanthrene derivative; toluene dioxygenase; unclassified drug; article; biotransformation; cis isomer; crystal structure; deprotection reaction; drug structure; drug synthesi

URI

http://hdl.handle.net/1885/51112

Collections

ANU Research Publications

Source

Tetrahedron

Type

Journal article

DOI

10.1016/j.tet.2008.01.113

Restricted until

2037-12-31

Downloads

File

Description

01_Matveenko_A_chemoenzymatic_total_2008.pdf (374.6 KB)