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Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-Methyl-D-aspartate receptors

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Date

2004

Authors

Kloda, Anna
Clements, John D
Lewis, Richard J
Adams, David

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Pharmacology and Experimental Therapeutics

Abstract

ATP and glutamate are fast excitatory neurotransmitters in the central nervous system acting primarily on ionotropic P2X and glutamate [N-methyl-D-aspartate (NMDA) and non-NMDA] receptors, respectively. Both neurotransmitters regulate synaptic plasticity

Description

Keywords

Keywords: adenosine diphosphate; adenosine triphosphate; cytidine triphosphate; glutamic acid; guanosine triphosphate; n methyl dextro aspartic acid receptor; neurotransmitter; purine P2X receptor; uridine triphosphate; agonist; allosterism; animal cell; article; b

Citation

URI

http://hdl.handle.net/1885/81051

Collections

ANU Research Publications

Source

Molecular Pharmacology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1124/mol.65.6.1386

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