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TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines

Date

Authors

Tyne, Anneliese S.

Chan, John Gar Yan

Shanahan, Erin R.

Atmosukarto, Ines

Chan, Hak-Kim

Britton, Warwick

West, Nicholas P.

Publisher

Elsevier

Abstract

Despite considerable research efforts towards effective treatments, tuberculosis (TB) remains a staggering burden on global health. Suitably formulated sub-unit vaccines offer potential as safe and effective generators of protective immunity. The Mycobact

Keywords

Keywords: bacterial protein; immunoglobulin G; lipokel; Mycobacterium vaccine; unclassified drug; antibody response; antigen presenting cell; article; controlled study; dendritic cell; dry powder; female; immunization; lung tuberculosis; mediastinum lymph node; mou Cutinase-like protein1-6; Lipokel; MPT83; Powdered pulmonary vaccine; TLR-2; Tuberculosis

URI

http://hdl.handle.net/1885/66093

Collections

ANU Research Publications

Source

Vaccine

Type

Journal article

DOI

10.1016/j.vaccine.2013.07.022

Restricted until

2037-12-31

Downloads

File

Description

01_Tyne_TLR2-targeted_secreted_2013.pdf (1.29 MB)