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The structure of the hexameric atrazine chlorohydrolase AtzA

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dc.contributor.authorPeat, T. S.
dc.contributor.authorNewman, J.
dc.contributor.authorBalotra, S.
dc.contributor.authorLucent, D.
dc.contributor.authorWarden, A. C.
dc.contributor.authorScott, C.
dc.date.accessioned2015-05-06T07:10:44Z
dc.date.available2015-05-06T07:10:44Z
dc.date.issued2015-03
dc.date.updated2015-12-10T09:35:48Z
dc.description.abstractAtrazine chlorohydrolase (AtzA) was discovered and purified in the early 1990s from soil that had been exposed to the widely used herbicide atrazine. It was subsequently found that this enzyme catalyzes the first and necessary step in the breakdown of atrazine by the soil organism Pseudomonas sp. strain ADP. Although it has taken 20 years, a crystal structure of the full hexameric form of AtzA has now been obtained. AtzA is less well adapted to its physiological role (i.e. atrazine dechlorination) than the alternative metal-dependent atrazine chlorohydrolase (TrzN), with a substrate-binding pocket that is under considerable strain and for which the substrate is a poor fit.
dc.identifier.issn1399-0047en_AU
dc.identifier.urihttp://hdl.handle.net/1885/13399
dc.publisherInternational Union of Crystallography
dc.rightshttp://www.sherpa.ac.uk/romeo/issn/0907-4449/..."Publisher's version/PDF may be used (authorised electronic re-print) (preferred). On author's personal website, employer's website, employer's repository, or subject-based repository" from SHERPA/RoMEO site (as at 6/5/15)
dc.sourceActa Crystallographica Section D Biological Crystallography
dc.subjectatrazine chlorohydrolase
dc.titleThe structure of the hexameric atrazine chlorohydrolase AtzA
dc.typeJournal article
local.bibliographicCitation.issue3en_AU
local.bibliographicCitation.lastpage720en_AU
local.bibliographicCitation.startpage710en_AU
local.contributor.affiliationBalotra, S., Research School of Chemistry, The Australian National Universityen_AU
local.contributor.authoruidU4988008en_AU
local.identifier.absfor030403 - Characterisation of Biological Macromolecules
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
local.identifier.ariespublicationu4005981xPUB904
local.identifier.citationvolume71en_AU
local.identifier.doi10.1107/S1399004715000619en_AU
local.identifier.essn1399-0047en_AU
local.identifier.scopusID2-s2.0-84924764994
local.publisher.urlhttp://www.iucr.org/en_AU
local.type.statusPublished Versionen_AU

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