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Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series

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Date

2003

Authors

Stoll, Vincent
Stewart, Kent
Maring, Clarence
Muchmore, Steven
Giranda, Vincent
Gu, Yu-gui
Wang, Gary
Chen, Yuanwei
Sun, Minghua
Zhao, Chen

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

Combinatorial and structure-based medicinal chemistry strategies were used together to advance a lead compound with an activity of Ki = 58 μM via a potency enhancement of < 70 000-fold to an analogue with an activity of Ki = 0.8 nM against influenza neur

Description

Keywords

Keywords: Binding modes; Crystal structure; Lead compounds; Proteins; Biochemistry; 4 acetamido 5 amino 3 (1 ethylpropoxy) 1 cyclohexene 1 carboxylic acid; cyclopentane derivative; pyrrolidine derivative; sialidase inhibitor; virus sialidase; zanamivir; article; co

Citation

URI

http://hdl.handle.net/1885/75368

Collections

ANU Research Publications

Source

Biochemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/bi0205449

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