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The role of symptomatic presentation in influenza A transmission risk

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dc.contributor.authorWardell, Rebecca
dc.contributor.authorPrem, K.
dc.contributor.authorCowling, Benjamin
dc.contributor.authorCook, Alex R
dc.date.accessioned2021-10-04T21:45:45Z
dc.date.available2021-10-04T21:45:45Z
dc.date.issued2017
dc.date.updated2020-11-23T11:20:12Z
dc.description.abstractComputer models can be useful in planning interventions against novel strains of influenza. However such models sometimes make unsubstantiated assumptions about the relative infectivity of asymptomatic and symptomatic cases, or conversely assume there is no impact at all. Using household-level data from known-index studies of virologically confirmed influenza A infection, the relationship between an individual's infectiousness and their symptoms was quantified using a discrete-generation transmission model and Bayesian Markov chain Monte Carlo methods. It was found that the presence of particular respiratory symptoms in an index case does not influence transmission probabilities, with the exception of child-to-child transmission where the donor has phlegm or a phlegmy coughen_AU
dc.description.sponsorshipR.W. was supported by a New Colombo Plan scholarship from the Australian Department of Foreign Affairs and Trade (DFAT). K.P. and A.R.C. were supported by funding from the Ministry of Education, Ministry of Health, Ministry of Defence, and the National University Health System, all Singapore (grant nos. CDPHRG/ 0009/2014, NUHSR0/2013/142IH7N9104, PROJECT MODUS 9014100379). B.J.C. was supported by the National Institute of General Medical Sciences (grant U54 GM088558), a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. T11-705/14N), and a commissioned grant from the Health and Medical Research Fund from the Government of the Hong Kong Special Administrative Region. The original household trial in Hong Kong was supported by the United States Centers for Disease Control and Prevention (grant no. 1 U01 CI000439).en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0950-2688en_AU
dc.identifier.urihttp://hdl.handle.net/1885/250436
dc.language.isoen_AUen_AU
dc.provenancehttps://v2.sherpa.ac.uk/id/publication/1568..."published version can be made open access on any website" from SHERPA/RoMEO site (as at 5/10/21).en_AU
dc.publisherCambridge University Pressen_AU
dc.rights© Cambridge University Press 2016en_AU
dc.rights.licenseCreative Commons License (Attribution 4.0 International)en_AU
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_AU
dc.sourceEpidemiology and Infectionen_AU
dc.subjectBayesian statisticsen_AU
dc.subjectinfluenza Aen_AU
dc.subjectmodellingen_AU
dc.subjectsymptomsen_AU
dc.subjecttransmissionen_AU
dc.titleThe role of symptomatic presentation in influenza A transmission risken_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue4en_AU
local.bibliographicCitation.lastpage727en_AU
local.bibliographicCitation.startpage723en_AU
local.contributor.affiliationWardell, Rebecca, College of Health and Medicine, ANUen_AU
local.contributor.affiliationPrem, K., National University Health Systemen_AU
local.contributor.affiliationCowling, Benjamin, University of Hong Kong, School of Public Health, Hong Kongen_AU
local.contributor.affiliationCook, Alex R, National University of Singaporeen_AU
local.contributor.authoruidWardell, Rebecca, u5186705en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor110000 - MEDICAL AND HEALTH SCIENCESen_AU
local.identifier.ariespublicationa383154xPUB8595en_AU
local.identifier.citationvolume145en_AU
local.identifier.doi10.1017/S0950268816002740en_AU
local.identifier.scopusID2-s2.0-85002373911
local.identifier.thomsonID000398968800011
local.publisher.urlhttp://www.cambridge.org/uk/en_AU
local.type.statusPublished Versionen_AU

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