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Metabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum

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dc.contributor.authorTan, Kar-Chun
dc.contributor.authorTrengove, Robert
dc.contributor.authorMaker, Garth L.
dc.contributor.authorOliver, Richard Peter
dc.contributor.authorSolomon, Peter
dc.date.accessioned2015-12-07T22:15:06Z
dc.date.issued2009
dc.date.updated2016-02-24T11:15:23Z
dc.description.abstractA recent comparative proteomics study identified the short-chain dehydrogenase (Sch1) as being required for asexual sporulation (Tan et al. Eukaryotic Cell 7:1916-1929, 2008). Metabolite profiling was undertaken on the mutant strains of Stagonospora nodorum lacking the Sch1 gene to help elucidate its role. Gas chromatography-mass spectrometry of the polar metabolites in the Sch1 mutants identified a secondary metabolite at a 200-fold greater concentration than observed in the wild-type strains. Comparative analysis of the secondary metabolite and the mycotoxin alternariol using ESI-MS/MS confirmed the identity of the compound as alternariol. This is the first report to confirm the presence of a mycotoxin in S. nodorum and compelling the field to consider the health implication of this disease.
dc.identifier.issn1573-3882
dc.identifier.urihttp://hdl.handle.net/1885/17746
dc.publisherSpringer
dc.sourceMetabolomics
dc.subjectKeywords: Eukaryota; Phaeosphaeria nodorum Alternariol; Metabolomics; Mycotoxin; Pathogen; Stagonospora nodorum
dc.titleMetabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum
dc.typeJournal article
local.bibliographicCitation.lastpage335
local.bibliographicCitation.startpage330
local.contributor.affiliationTan, Kar-Chun, Murdoch University
local.contributor.affiliationTrengove, Robert, Murdoch University
local.contributor.affiliationMaker, Garth L., Murdoch University
local.contributor.affiliationOliver, Richard Peter, Murdoch University
local.contributor.affiliationSolomon, Peter, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidSolomon, Peter, u4632004
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060109 - Proteomics and Intermolecular Interactions (excl. Medical Proteomics)
local.identifier.absfor060101 - Analytical Biochemistry
local.identifier.ariespublicationu4632004xPUB2
local.identifier.citationvolume5
local.identifier.doi10.1007/s11306-009-0158-2
local.identifier.scopusID2-s2.0-70149092984
local.identifier.thomsonID000269312400006
local.type.statusPublished Version

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