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Airway Hyperreactivity in Exacerbation of Chronic Asthma is Independent of Eosinophilic Inflammation

Date

Authors

Siegle, Jessica S

Hansbro, Nicole

Herbert, Cristan

Yang, Ming

Foster, Paul S

Kumar, Rakesh K

Publisher

American Thoracic Society

Abstract

We have developed an animal model to investigate the mechanisms underlying an acute exacerbation of chronic asthma. Sensitized BALB/c mice were exposed to aerosolized ovalbumin, either as chronic low-level challenge (mass concentration ≈ 3 mg/m3) for 4

Keywords

Keywords: airway; animal experiment; animal model; animal tissue; article; asthma; bronchus hyperreactivity; controlled study; disease exacerbation; enzyme immunoassay; eosinophil; female; histopathology; inflammation; lung lavage; mouse; nonhuman; Animals; Asthma; Airway inflammation; Bronchial hyperreactivity; Eosinophils; Severe asthma; Small airways disease

URI

http://hdl.handle.net/1885/19400

Collections

ANU Research Publications

Source

American Journal of Respiratory Cell and Molecular Biology

Type

Journal article

DOI

10.1165/rcmb.2006-0135OC

Restricted until

2037-12-31

Downloads

File

Description

01_Siegle_Airway_Hyperreactivity_in_2006.pdf (975.67 KB)

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