Binding site stoichiometry and the effects of phosphorylation on human alpha 1 homomeric glycine receptors

Gentet, Luc; Clements, John D

Binding site stoichiometry and the effects of phosphorylation on human alpha 1 homomeric glycine receptors

Date

2002

Authors

Gentet, Luc

Clements, John D

Publisher

Cambridge University Press

Abstract

The kinetic properties of the human α1 homomeric glycine receptor were investigated. Receptors were expressed in HEK 293 cells, and glycine was applied to outside-out membrane patches with submillisecond solution exchange. The activation time course of t