An enantioselective total synthesis of the stilbenolignan (-)-aiphanol and the determination of its absolute stereochemistry

Abstract

The title natural product (-)-aiphanol has been prepared by total synthesis. A key step involved the asymmetric dihydroxylation of (E)-3,5-dimethoxy-4-(methoxymethoxy)cinnamyl alcohol with the AD-mix-β to give triol (1R,2R)-1-(3′,5′-dimethoxy-4′-me Show more