Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Chemical Ecogenomics-Guided Discovery of Phytotoxic a-Pyrones from the Fungal Wheat Pathogen Parastagonospora nodorum

Simple item page
dc.contributor.authorLi, Hang
dc.contributor.authorHu, Jinyu
dc.contributor.authorWei, Haochen
dc.contributor.authorPeter, Solomon
dc.contributor.authorVuong, Daniel
dc.contributor.authorLacey, E
dc.contributor.authorStubbs, Keith A
dc.contributor.authorPiggott, Andrew M.
dc.contributor.authorChooi, Yit-Heng
dc.date.accessioned2019-06-21T03:25:30Z
dc.date.issued2018
dc.date.updated2019-03-24T07:19:20Z
dc.description.abstractA biosynthetic gene cluster that is significantly upregulated in the fungal wheat pathogen Parastagonospora nodorum during plant infection was reconstructed heterologously in Aspergillus nidulans. This led to the discovery of five new α-pyrone polyketides, alternapyrones B-F (2-6). Compounds 5 and 6, which contain a highly substituted dihydrofuran, exhibited phytotoxicity on wheat seed germination. It is demonstrated that only three enzymes, one highly reducing polyketide synthase and two multifunctional P450 oxygenases, are needed to synthesize the structurally complex products.en_AU
dc.description.sponsorshipThis study was supported by an Australian Research Council (ARC) Discovery Project grant (DP170100228). H.L. and J.H. are supported by an Australian Government International Postgraduate Research Scholarship. Y.-H.C., K.A.S., and A.M.P. are ARC Future Fellows.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1523-7060en_AU
dc.identifier.urihttp://hdl.handle.net/1885/164145
dc.language.isoen_AUen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.relationhttp://purl.org/au-research/grants/arc/DP170100228en_AU
dc.rights© 2018 American Chemical Societyen_AU
dc.sourceOrganic Lettersen_AU
dc.titleChemical Ecogenomics-Guided Discovery of Phytotoxic a-Pyrones from the Fungal Wheat Pathogen Parastagonospora nodorumen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue19en_AU
local.bibliographicCitation.lastpage6152en_AU
local.bibliographicCitation.startpage6148en_AU
local.contributor.affiliationLi, Hang, The University of Western Australiaen_AU
local.contributor.affiliationHu, Jinyu, University of Western Australia,en_AU
local.contributor.affiliationWei, Haochen, College of Science, ANUen_AU
local.contributor.affiliationSolomon, Peter, College of Science, ANUen_AU
local.contributor.affiliationVuong, Daniel, Microbial Screening Technologies Pty Ltden_AU
local.contributor.affiliationLacey, E, Microbial Screening Technol. Pty Ltd.en_AU
local.contributor.affiliationStubbs, Keith A, University of Western Australiaen_AU
local.contributor.affiliationPiggott, Andrew M., Macquarie Universityen_AU
local.contributor.affiliationChooi, Yit-Heng, The University of Western Australiaen_AU
local.contributor.authoruidWei, Haochen, u6030062en_AU
local.contributor.authoruidSolomon, Peter, u4632004en_AU
local.description.embargo2037-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor060704 - Plant Pathologyen_AU
local.identifier.absfor060705 - Plant Physiologyen_AU
local.identifier.absfor030502 - Natural Products Chemistryen_AU
local.identifier.absseo820507 - Wheaten_AU
local.identifier.ariespublicationu4485658xPUB1274en_AU
local.identifier.citationvolume20en_AU
local.identifier.doi10.1021/acs.orglett.8b02617en_AU
local.identifier.scopusID2-s2.0-85053687329
local.publisher.urlhttps://pubs.acs.org/en_AU
local.type.statusPublished Versionen_AU

Downloads

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
01_Li_Chemical_Ecogenomics-Guided_2018.pdf
Size:
1.97 MB
Format:
Adobe Portable Document Format
Download

Collections

ANU Research Publications

DSpace software copyright © 2002-2026 LYRASIS