Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoidarthritis
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Stack, John R.
Madigan, Anne
Helbert, Laura
Dunne, E.
Gardiner, Elizabeth
Andrews, Robert K.
Finan, Roisin
Smyth, Elizabeth
Kenny, D.
McCarthy, Geraldine
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Public Library of Science
Abstract
Anti-citrullinated protein antibodies (ACPA) have been shown to cause platelet activation in
vitro, through the low-affinity immunoglobulin G (IgG) receptor (FcγRIIa) on platelets. Platelet
activation via engagement of FcγRIIa results in proteolytic cleavage and shedding of
platelet specific glycoprotein VI (GPVI) which can be detected in the plasma as soluble
GPVI (sGPVI). We hypothesized that plasma levels of sGPVI would be increased among
patients with seropositive RA as a consequence of antibody-induced platelet activation and
GPVI shedding.
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PLOS ONE (Public Library of Science)
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