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Fowlpox virus vaccines for HIV and SHIV clinical and pre-clinical trials

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dc.contributor.authorCoupar, Barbara E H
dc.contributor.authorPurcell, Damian F J
dc.contributor.authorThomson, Scott
dc.contributor.authorRamshaw, Ian
dc.contributor.authorKent, Stephen J
dc.contributor.authorBoyle, David B
dc.date.accessioned2015-12-13T23:02:04Z
dc.date.issued2006
dc.date.updated2015-12-12T07:44:34Z
dc.description.abstractDNA prime and recombinant fowlpox virus (rFPV) boost vaccines were designed to express multiple HIV or SIV antigens for use in human clinical trials and in pre-clinical trials in macaques. Three sets of vaccines with matching HIV or SIV antigen sets, modified for vaccine safety considerations, were constructed and shown to express the relevant proteins. The rFPV vaccines with inserts at up to three sites, were stable on passage in chick cell culture, including during GMP manufacture of vaccines for human Phase I clinical trials. Cellular and humoral immunogenicity in mice was demonstrated using a DNA prime/rFPV boost and vaccinia virus challenge model. These data establish a preliminary safety and efficacy profile for these multigenic vaccines suggesting they are suitable for advanced development as candidate HIV vaccines.
dc.identifier.issn0264-410X
dc.identifier.urihttp://hdl.handle.net/1885/84714
dc.publisherElsevier
dc.sourceVaccine
dc.subjectKeywords: DNA vaccine; fowlpox virus vaccine; Human immunodeficiency virus vaccine; primer DNA; recombinant vaccine; unclassified drug; virus antigen; virus vaccine; animal cell; animal experiment; animal model; article; cell culture; cellular immunity; chick; cont DNA; HIV vaccine; Prime/boost; Recombinant fowlpox virus
dc.titleFowlpox virus vaccines for HIV and SHIV clinical and pre-clinical trials
dc.typeJournal article
local.bibliographicCitation.lastpage1388
local.bibliographicCitation.startpage1378
local.contributor.affiliationCoupar, Barbara E H, Duke University
local.contributor.affiliationPurcell, Damian F J, University of Melbourne
local.contributor.affiliationThomson, Scott, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationRamshaw, Ian, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKent, Stephen J, University of Melbourne
local.contributor.affiliationBoyle, David B, CSIRO Division of Livestock Industries
local.contributor.authoruidThomson, Scott, u9711363
local.contributor.authoruidRamshaw, Ian, u8202754
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110799 - Immunology not elsewhere classified
local.identifier.ariespublicationMigratedxPub12970
local.identifier.citationvolume24
local.identifier.doi10.1016/j.vaccine.2005.09.044
local.identifier.scopusID2-s2.0-32344445678
local.type.statusPublished Version

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