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The Need for translational research on antidotes for pesticide poisoning

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dc.contributor.authorBuckley, Nicholas
dc.contributor.authorEddleston, Michael
dc.contributor.authorDawson, Andrew
dc.date.accessioned2015-12-13T23:00:35Z
dc.date.issued2005
dc.date.updated2015-12-12T07:34:57Z
dc.description.abstract1. Pesticide poisoning kills hundreds of thousands of people in the Asia-Pacific region each year. The majority of deaths are from deliberate self-poisoning with organophosphorus pesticides (OP), aluminium phosphide and paraquat. The current response from a public health, medical and research perspective is inadequate. 2. There are few proven or effective treatments; in addition, very little clinical research has been performed to transfer antidotes shown to work in animal studies into clinical practice. 3. The human toxicity of pesticides is poorly studied and better information may inform a more sustained and appropriate regulatory response. Further understanding may also lead to improvements in diagnosis and treatment. 4. The few effective treatments are not being recommended or delivered in an optimal and timely fashion to poisoned patients. A regional approach to facilitate appropriate pricing, packaging and delivery of antidotes is required.
dc.identifier.issn0305-1870
dc.identifier.urihttp://hdl.handle.net/1885/84187
dc.publisherBlackwell Science Asia
dc.sourceClinical and Experimental Pharmacology and Physiology
dc.subjectKeywords: acetylcholinesterase; acetylcysteine; activated carbon; aluminum phosphide; antidote; atropine; bicarbonate; carbamate pyridostigmine; cyclophosphamide; deferoxamine; diazepam; digoxin antibody F(ab) fragment; flumazenil; hydroxocobalamin; methylprednisol Antidotes; Organophosphorus; Paraquat; Pesticide; Poisoning
dc.titleThe Need for translational research on antidotes for pesticide poisoning
dc.typeJournal article
local.bibliographicCitation.lastpage1005
local.bibliographicCitation.startpage999
local.contributor.affiliationBuckley, Nicholas, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationEddleston, Michael, University of Oxford
local.contributor.affiliationDawson, Andrew, University of Peradeniya
local.contributor.authoruidBuckley, Nicholas, a150111
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor111506 - Toxicology (incl. Clinical Toxicology)
local.identifier.ariespublicationMigratedxPub12452
local.identifier.citationvolume32
local.identifier.doi10.1111/j.1440-1681.2005.04298.x
local.identifier.scopusID2-s2.0-33745204824
local.type.statusPublished Version

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