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The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer

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dc.contributor.authorMurchison, Elizabeth
dc.contributor.authorTovar, Cesar
dc.contributor.authorHsu, Arthur Lian-Chi
dc.contributor.authorBender, Hannah
dc.contributor.authorKheradpour, Pouya
dc.contributor.authorRebbeck, Clare A.
dc.contributor.authorObendorf, David
dc.contributor.authorConlan, Carly
dc.contributor.authorBahlo, Melanie
dc.contributor.authorBlizzard, Catherine A.
dc.contributor.authorPyecroft, Stephen
dc.contributor.authorKreiss, Alexandre
dc.contributor.authorKellis, Manolis
dc.contributor.authorStark, Alexander
dc.contributor.authorHarkins, Timothy T.
dc.contributor.authorGraves, Jennifer
dc.contributor.authorWoods, Greg
dc.contributor.authorHannon, Gregory
dc.contributor.authorPapenfuss, Anthony T
dc.date.accessioned2015-12-10T22:56:48Z
dc.date.issued2010
dc.date.updated2016-02-24T12:06:44Z
dc.description.abstractThe Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.
dc.identifier.issn0036-8075
dc.identifier.urihttp://hdl.handle.net/1885/60383
dc.publisherAmerican Association for the Advancement of Science
dc.sourceScience
dc.subjectKeywords: microRNA; microsatellite DNA; transcriptome; cancer; carnivore; data set; genetic analysis; genetic marker; genome; pathology; RNA; allograft; animal tissue; article; cancer diagnosis; conservation biology; controlled study; devil facial tumor disease; di
dc.titleThe Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer
dc.typeJournal article
local.bibliographicCitation.issue84
local.bibliographicCitation.lastpage87
local.bibliographicCitation.startpage84
local.contributor.affiliationMurchison, Elizabeth, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTovar, Cesar, University of Tasmania
local.contributor.affiliationHsu, Arthur Lian-Chi, Walter and Eliza Hall Institute of Medical Research
local.contributor.affiliationBender, Hannah, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKheradpour, Pouya, Massachusetts Institute of Technology
local.contributor.affiliationRebbeck, Clare A., Howard Hughes Medical Institute
local.contributor.affiliationObendorf, David, University of Tasmania
local.contributor.affiliationConlan, Carly, Howard Hughes Medical Institute
local.contributor.affiliationBahlo, Melanie, Walter and Eliza Hall Institute of Medical Research
local.contributor.affiliationBlizzard, Catherine A., University of Tasmania
local.contributor.affiliationPyecroft, Stephen, TAS Department of Primary Industries and Water
local.contributor.affiliationKreiss, Alexandre, University of Tasmania
local.contributor.affiliationKellis, Manolis, Massachusetts Institute of Technology
local.contributor.affiliationStark, Alexander, Massachusetts Institute of Technology
local.contributor.affiliationHarkins, Timothy T., Roche Applied Sciences
local.contributor.affiliationGraves, Jennifer, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWoods, Greg, University of Tasmania
local.contributor.affiliationHannon, Gregory, Watson School of Biological Sciences
local.contributor.affiliationPapenfuss, Anthony T, Walter and Eliza Hall Institute of Medical Research
local.contributor.authoruidMurchison, Elizabeth, u4582805
local.contributor.authoruidBender, Hannah, u4321663
local.contributor.authoruidGraves, Jennifer, u4021869
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060405 - Gene Expression (incl. Microarray and other genome-wide approaches)
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.ariespublicationu9511635xPUB536
local.identifier.citationvolume327
local.identifier.doi10.1126/science.1180616
local.identifier.scopusID2-s2.0-74949085550
local.identifier.thomsonID000273395400036
local.type.statusPublished Version

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