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Autoimmune diabetes in the NOD mouse: an essential role of Fas-FasL signaling in β cell apoptosis

Date

Authors

Silva, Diego

Socha, L

Charlton, Brett

Cowden, William

Petrovsky, Nikolai

Publisher

New York Academy of Sciences

Abstract

Despite evidence that both Fas and FasL can be expressed in pancreatic islets, there has been considerable controversy regarding the potential role of Fas signaling in autoimmune β cell death. Using the HIPFasL model, we have been able to demonstrate tha

Keywords

Keywords: cytokine; Fas antigen; FAS ligand; gamma interferon; interleukin 1; animal experiment; animal model; animal tissue; apoptosis; autoimmune disease; cell infiltration; conference paper; controlled study; histopathology; immunopathogenesis; insulin dependent Apoptosis; Autoimmunity; Fas ligand; NOD; Type 1 diabetes

URI

http://hdl.handle.net/1885/87776

Collections

ANU Research Publications

Source

Annals of the New York Academy of Sciences

Type

Journal article

DOI

10.1196/annals.1288.018

Restricted until

2037-12-31

Downloads

File

Description

01_Silva_Autoimmune_diabetes_in_the_NOD_2003.pdf (1.28 MB)