Leptin: Molecular mechanisms, systemic pro-inflammatory effects, and clinical implications [Leptina: Mecanismos moleculares, efeitos proinflamatorios sistmicos e implicoes clinicas]

Date

2012

Authors

Da Paz Filho, Gilberto
Mastronardi, Claudio
Franco, CB
Wang, Kevin
Wong, Ma-Li
Licinio, Julio

Journal Title

Journal ISSN

Volume Title

Publisher

Universidade de Sao Paulo, Faculdade de Medicina

Abstract

Leptin, the adipokine produced mainly by the white adipose tissue, plays important roles not only in the regulation of food intake, but also in controlling immunity and inflammation. It has been widely demonstrated that the absence of leptin leads to immune defects in animal and human models, ultimately increasing mortality. Leptin also regulates inflammation by means of actions on its receptor, that is widely spread across different immune cell populations. The molecular mechanisms by which leptin determines its biological actions have also been recently elucidated, and three intracellular pathways have been implicated in leptin actions: JAK-STAT, PI3K, and ERK 1/2. These pathways are closely regulated by intracellular proteins that decrease leptin biological activity. In this review, we discuss the molecular mechanisms by which leptin regulates immunity and inflammation, and associate those mechanisms with chronic inflammatory disorders.

Description

Keywords

Keywords: autacoid; cytokine; immunologic factor; leptin; leptin receptor; adaptive immunity; animal; chronic disease; disease model; human; immunology; inflammation; metabolism; physiology; review; Adaptive Immunity; Animals; Chronic Disease; Cytokines; Disease Mo Cytokines; Immunity; Inflammation; Leptin

Citation

Source

Arquivos Brasileiros de Endocrinologia e Metabologia

Type

Journal article

Book Title

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Access Statement

License Rights

DOI

10.1590/S0004-27302012000900001

Restricted until

2037-12-31