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Stem rust resistance in wheat is suppressed by a subunit of the mediator complex

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dc.contributor.authorHiebert, Colin W.
dc.contributor.authorMoscou, Matthew J.
dc.contributor.authorHewitt, Tim
dc.contributor.authorSteuernagel, Burkhard
dc.contributor.authorGreen, Phon
dc.contributor.authorZhang, Peng
dc.contributor.authorPujol, Vincent
dc.contributor.authorRouse, Matthew
dc.contributor.authorJin, Yue
dc.contributor.authorMcIntosh, Robert A.
dc.contributor.authorUpadhyaya, Narayana M
dc.date.accessioned2023-04-05T00:22:28Z
dc.date.available2023-04-05T00:22:28Z
dc.date.issued2020
dc.date.updated2022-01-23T07:17:19Z
dc.description.abstractStem rust is an important disease of wheat that can be controlled using resistance genes. The gene SuSr-D1 identified in cultivar 'Canthatch' suppresses stem rust resistance. SuSr-D1 mutants are resistant to several races of stem rust that are virulent on wild-type plants. Here we identify SuSr-D1 by sequencing flow-sorted chromosomes, mutagenesis, and map-based cloning. The gene encodes Med15, a subunit of the Mediator Complex, a conserved protein complex in eukaryotes that regulates expression of protein-coding genes. Nonsense mutations in Med15b.D result in expression of stem rust resistance. Time-course RNAseq analysis show a significant reduction or complete loss of differential gene expression at 24 h post inoculation in med15b.D mutants, suggesting that transcriptional reprogramming at this time point is not required for immunity to stem rust. Suppression is a common phenomenon and this study provides novel insight into suppression of rust resistance in wheat.en_AU
dc.description.sponsorshipThis work was supported in part by funds provided through Agriculture and Agri-Food Canada, Western Grains Research Foundation, Biotechnology and Biological Sciences Research Council (BB/P012574/1, BB/P016855/1), National Science Foundation (NSF BREAD program IOS-0965429), CSIRO, Gatsby Foundation, and the ERDF project “Plants as a tool for sustainable global development” (No. CZ.02.1.01/0.0/0.0/16_019/ 0000827). We thank Peter Dodds and Jeff Ellis for critical review of the manuscript prior to submission. We acknowledge the technical expertize of M. Popovic, G. Mardli, D. Edwards, T. Malasiuk, T. Zegeye, Z. Dubská, J. Weiserová, R. Šperková, W. Schnippenkoetter, and S. Chandramohan. We thank D. Klindworth and S. Xu for providing seed of mutant lines developed at the USDA (Fargo, North Dakota).en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2041-1723en_AU
dc.identifier.urihttp://hdl.handle.net/1885/288108
dc.language.isoen_AUen_AU
dc.provenanceThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_AU
dc.publisherMacmillan Publishers Ltden_AU
dc.rights© 2020 The authorsen_AU
dc.rights.licenseCreative Commons Attribution licenceen_AU
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_AU
dc.sourceNature Communicationsen_AU
dc.titleStem rust resistance in wheat is suppressed by a subunit of the mediator complexen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.contributor.affiliationHiebert, Colin W., Morden Research and Development Centreen_AU
local.contributor.affiliationMoscou, Matthew J., University of East Angliaen_AU
local.contributor.affiliationHewitt, Tim, CSIRO Agriculture & Fooden_AU
local.contributor.affiliationSteuernagel, Burkhard, John Innes Centreen_AU
local.contributor.affiliationGreen, Phon, University of East Angliaen_AU
local.contributor.affiliationZhang, Peng , University of Sydneyen_AU
local.contributor.affiliationPujol, Vincent, College of Science, ANUen_AU
local.contributor.affiliationRouse, Matthew , University of Minnesotaen_AU
local.contributor.affiliationJin, Yue, University of Minnesotaen_AU
local.contributor.affiliationMcIntosh, Robert A., University of Sydneyen_AU
local.contributor.affiliationUpadhyaya, Narayana M, CSIRO Plant Industryen_AU
local.contributor.authoruidPujol, Vincent, u4948853en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor310806 - Plant physiologyen_AU
local.identifier.absseo280102 - Expanding knowledge in the biological sciencesen_AU
local.identifier.ariespublicationa383154xPUB10729en_AU
local.identifier.citationvolume11en_AU
local.identifier.doi10.1038/s41467-020-14937-2en_AU
local.publisher.urlhttps://www.nature.com/en_AU
local.type.statusPublished Versionen_AU

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