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A Newly Classified Vertebrate Calpain Protease, Directly Ancestral to CAPN1 and 2, Episodically Evolved a Restricted Physiological Function in Placental Mammals

Date

Authors

Macqueen, Daniel J.

Delbridge, Margaret

Manthri, Sujatha

Johnston, Ian A.

Publisher

Society for Molecular Biology Evolution

Abstract

The most studied members of the calpain protease superfamily are CAPN1 and 2, which are conserved across vertebrates. Another similar family member called μ/m-CAPN has been identified in birds alone. Here, we establish that μ/m-CAPN shares one-to-one or

Keywords

Keywords: calpain; calpain 1; calpain 11; calpain 2; calpastatin; unclassified drug; amino acid sequence; article; gene control; gene expression; gene mutation; genetic code; genetic transcription; marsupial; molecular evolution; monophyly; nonhuman; orthology; pla CAPN11 and µ/m-CAPN; Dykhuizen-Hartl effect; episodic gene evolution; functional constraints; functional divergence of gene family orthologues; transcriptional regulation

URI

http://hdl.handle.net/1885/61966

Collections

ANU Research Publications

Source

Molecular Biology and Evolution

Type

Journal article

DOI

10.1093/molbev/msq071

Restricted until

2037-12-31

Downloads

File

Description

01_Macqueen_A_Newly_Classified_Vertebrate_2010.pdf (1.92 MB)