Hippocampus and amygdala volumes in a random community-based sample of 60-64 year olds and their relationship to cognition Psychiatric Research: Neuroimaging

Date

2007

Authors

Maller, Jerome
Meslin, Chantal
Christensen, Helen
Sachdev, Perminder Singh
Anstey, Kaarin

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

Reduced volumes of the hippocampus (HC) and amygdala (AG) are potential biomarkers for Alzheimer's disease (AD) and other neuropsychiatric disorders. Published studies on HC and AG volumes suffer from methodological limitations, and a valid and reliable normative database does not exist. This study aimed to establish a database of HC and AG volumes from a large community sample of participants 60-64 years old and relate them to cognition. A total of 452 randomly selected participants (from 622 approached) were retained in the study (238 males, 214 females), and all received brain MRI scans, as well as cognitive and physical assessments. HC and AG volumes were estimated from manual tracings on T1-weighted images, and intracranial volume (ICV) was obtained from an automated program. In both sexes, right hippocampi were larger than left, while left amygdalae were larger than right. The only correlation to remain significant after normalization was left HC volume and percent retention of a word list in females. This study provides a HC and AG volumetrics database and describes its relationship with cognitive performance in a representative sample using a standard methodology that will be a reference for future studies. It will therefore have clinical applicability in early AD and other disorders.

Description

Keywords

Keywords: adult; aged; amygdaloid nucleus; article; behavioral science; brain function; brain region; cognition; controlled study; correlation analysis; demography; female; hippocampus; human; human experiment; male; memory; neuroimaging; nuclear magnetic resonance Amygdale; Hippocampus; Memory; MRI; Sex; Volumetrics

Citation

Source

Psychiatry Research: Neuroimaging

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.pscychresns.2007.06.005

Restricted until

2037-12-31