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Kinetics of the Biotransformation of Maleylacetone and Chlorofluoroacetic Acid by Polymorphic Variants of Human Glutathione Transferase Zeta (hGSTZ1-1)

Date

Authors

Lantum, Hoffman

Board, Philip

Anders, Michael

Publisher

American Chemical Society

Abstract

Glutathione transferase zeta (GSTZ1-1) catalyzes the cis-trans isomerization of maleylacetoacetate and the biotransformation of a range of α-haloacids. The objective of this study was to determine the kinetics of the biotransformation of maleylacetone (M

Keywords

Keywords: acetic acid derivative; acetone; chlorofluoroacetic acid; deoxycorticosterone acetate; enzyme variant; glutathione transferase; haloacid; maleylacetoacetate; maleylacetone; meta tyrosine; unclassified drug; amino acid metabolism; article; biotransformatio

URI

http://hdl.handle.net/1885/73154

Collections

ANU Research Publications

Source

Chemical Research in Toxicology

Type

Journal article

DOI

10.1021/tx010095y

Restricted until

2037-12-31

Downloads

File

Description

01_Lantum_Kinetics_of_the_2002.pdf (155.88 KB)