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Convenient targeting of stealth siRNA-lipoplexes to cells with chelator lipid-anchored molecules

Date

Authors

Herringson, Thomas

Altin, Joseph

Publisher

Elsevier

Abstract

A major obstacle for the use of siRNAs as novel therapeutics is the requirement for functional delivery to specific cells in vivo. siRNA delivery by cationic agents is generally non-specific and a convenient targeting strategy has been lacking. This work

Keywords

Keywords: Chelator lipid; DODAP; Small interfering siRNA (siRNA); Stealth liposomes; Targeted delivery; Amines; Cell culture; Chelation; Dendrimers; Internet; Liposomes; Phospholipids; Propane; Targets; Tumors; Cell membranes; 1,2 dioleoyl 3 trimethylammoniopropane Chelator lipid; DODAP; Small interfering siRNA (siRNA); Stealth liposomes; Targeted delivery

URI

http://hdl.handle.net/1885/52246

Collections

ANU Research Publications

Source

Journal of Controlled Release

Type

Journal article

DOI

10.1016/j.jconrel.2009.06.034

Restricted until

2037-12-31

Downloads

File

Description

01_Herringson_Convenient_targeting_of_2009.pdf (499.3 KB)

02_Herringson_Convenient_targeting_of_2009.pdf (499.29 KB)

03_Herringson_Convenient_targeting_of_2009.pdf (783.5 KB)