Exhaustion of Type I interferon response following an acute viral infection

Date

2006

Authors

Alsharifi, Mohammed
Regner, Matthias
Blanden, Robert
Lobigs, Mario
Lee, Eva
Koskinen, Aulikki
Mullbacher, Arno

Journal Title

Journal ISSN

Volume Title

Publisher

American Association of Immunologists

Abstract

Viral infections often cause a period of heightened susceptibility to a secondary infection but the cause of this phenomenon is unknown. We found that a primary viral infection in mice rapidly triggers an IFN-I-dependent partial activation state in the majority of B and T lymphocytes, which reverts to a resting phenotype within 5 days. When a secondary infection with an unrelated virus occurred 5 to 9 days after the primary infection, no recurrence of marked activation of lymphocytes was observed. This was not due to an inherent inability of the previously activated cells to undergo renewed partial activation, because they responded when challenged with virus after transfer into "naive" recipients. Instead, the failure to respond optimally resided in the original host's incapacity to mount an IFN-I response to the secondary infection during this time period. Thus, transient immunosuppression through exhaustion of IFN-I production during an acute viral infection creates a time period of enhanced susceptibility to secondary infection.

Description

Keywords

Keywords: alpha interferon; CD45 antigen; glycoprotein p 15095; animal cell; animal experiment; animal model; animal tissue; article; B lymphocyte; controlled study; cytokine production; female; immune deficiency; infection sensitivity; lymphocyte activation; mouse

Citation

Source

Journal of Immunology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

Restricted until

2037-12-31