Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Transient NK Cell Depletion Facilitates Pulmonary Osteosarcoma Metastases After Intravenous Inoculation in Athymic Mice

Simple item page
dc.contributor.authorHarris, Michael A
dc.contributor.authorShekhar, Tanmay M
dc.contributor.authorCoupland, Lucy
dc.contributor.authorMiles, Mark A
dc.contributor.authorHawkins, Christine J
dc.date.accessioned2021-01-19T02:45:19Z
dc.date.issued2020
dc.date.updated2022-08-21T08:16:59Z
dc.description.abstractTwo thirds of metastatic osteosarcoma patients die within 5 years of diagnosis. Improved experimental models of osteosarcoma metastasis will facilitate the development of more effective therapies. Intravenous cancer cell injection can produce lung metastases in nude mice, but this ‘‘experimental metastasis’’ technique has been predominantly applied to a single osteosarcoma cell line (143B) and required injection of 1–2 million cells. Using two human osteosarcoma cell lines, we discovered that transient Natural Killer cell depletion dramatically enhanced the efficiency of experimental pulmonary osteosarcoma metastasis. This technique for modeling osteosarcoma metastasis may enable the identification of better treatments for this aggressive cancer.
dc.description.sponsorshipThis study was funded by grants from The Kids’ Cancer Project, Tour de Cure, and a Grant-in-Aid from the Cancer Council Victoria.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2156-5333en_AU
dc.identifier.urihttp://hdl.handle.net/1885/219773
dc.language.isoen_AUen_AU
dc.publisherMary Ann Liebert. Inc. Publishers
dc.rights© Mary Ann Liebert, Inc.
dc.sourceJournal of Adolescent and Young Adult Oncology (JAYAO)
dc.subjectosteosarcoma
dc.subjectbone cancer
dc.subjectxenograft
dc.subjectmetastasis
dc.subjectNatural Killer cells
dc.titleTransient NK Cell Depletion Facilitates Pulmonary Osteosarcoma Metastases After Intravenous Inoculation in Athymic Mice
dc.typeJournal article
local.bibliographicCitation.issue6
local.bibliographicCitation.lastpage5en_AU
local.bibliographicCitation.startpage1en_AU
local.contributor.affiliationHarris, Michael A, La Trobe Universityen_AU
local.contributor.affiliationShekhar, Tanmay M, La Trobe Universityen_AU
local.contributor.affiliationCoupland, Lucy, College of Health and Medicine, ANUen_AU
local.contributor.affiliationMiles, Mark A, La Trobe Universityen_AU
local.contributor.affiliationHawkins, Christine J, La Trobe Universityen_AU
local.contributor.authoruidCoupland, Lucy, u3562509en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor110709 - Tumour Immunologyen_AU
local.identifier.absfor111201 - Cancer Cell Biologyen_AU
local.identifier.absseo920102 - Cancer and Related Disordersen_AU
local.identifier.ariespublicationu1042365xPUB45en_AU
local.identifier.citationvolume9
local.identifier.doi10.1089/jayao.2019.0172en_AU
local.identifier.scopusID2-s2.0-85088022849
local.identifier.thomsonIDWOS:000532135700001
local.publisher.urlhttps://home.liebertpub.com/publications/journal-of-adolescent-and-young-adult-oncology/387en_AU
local.type.statusPublished Versionen_AU

Downloads

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
01_Harris_Transient_NK_Cell_Depletion_2020.pdf
Size:
582.12 KB
Format:
Adobe Portable Document Format
Download

Collections

ANU Research Publications

DSpace software copyright © 2002-2026 LYRASIS