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Polymorphism in endothelial connexin40 enhances sensitivity to intraluminal pressure and increases arterial stiffness

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Date

2013

Authors

Chaston, Daniel
Baillie, Brett
Grayson, Thomas
Courjaret, Raphael J
Heisler, Jillian M
Lau, Katherine A
Machaca, Khaled
Nicholson, Bruce
Ashton, Anthony
Matthaei, Klaus

Journal Title

Journal ISSN

Volume Title

Publisher

Lippincott Williams & Wilkins

Abstract

OBJECTIVE - : To determine whether impairment of endothelial connexin40 (Cx40), an effect that can occur in hypertension and aging, contributes to the arterial dysfunction and stiffening in these conditions. APPROACH AND RESULTS - : A new transgenic mouse

Description

Keywords

Keywords: calcitonin gene related peptide; connexin 40; nitric oxide; phenylephrine; animal cell; animal experiment; animal tissue; arterial stiffness; artery diameter; article; body weight; connexin 40 gene; controlled study; diastolic blood pressure; electric con arterial dysfunction; connexin40; endothelium; myogenic response; stiffness

Citation

URI

http://hdl.handle.net/1885/72478

Collections

ANU Research Publications

Source

Arteriosclerosis Thrombosis and Vascular Biology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1161/ATVBAHA.112.300957

Restricted until

2037-12-31

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Description
01_Chaston_Polymorphism_in_endothelial_2013.pdf (2.43 MB)

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