A single amino acid substitution in the West Nile Virus nonstructural protein NS2A disables its ability to inhibit alpha/beta interferon induction and attenuates virus virulence in mice

Liu, Weihua; Wang, Xiang; Clark, David C; Lobigs, Mario; Hall, Roy A; Khromykh, Alexander A

A single amino acid substitution in the West Nile Virus nonstructural protein NS2A disables its ability to inhibit alpha/beta interferon induction and attenuates virus virulence in mice

Date

2006

Authors

Liu, Weihua

Wang, Xiang

Clark, David C

Lobigs, Mario

Hall, Roy A

Khromykh, Alexander A

Publisher

American Society for Microbiology

Abstract

Alpha/beta interferons (IFN-α/β) are key mediators of the innate immune response against viral infection. The ability of viruses to circumvent IFN-α/β responses plays a crucial role in determining the outcome of infection. In a previous study using su