Plasticity of human chromosome 3 during primate evolution

dc.contributor.authorTsend-Ayush, Enkhjargal
dc.contributor.authorGruetzner, Frank
dc.contributor.authorYue, Ying
dc.contributor.authorGrossmann, Barbel
dc.contributor.authorHansel, Ulrike
dc.contributor.authorSudbrak, Ralf
dc.contributor.authorHaaf, Thomas
dc.date.accessioned2015-12-13T23:14:37Z
dc.date.issued2004
dc.date.updated2015-12-12T08:39:37Z
dc.description.abstractComparative mapping of more than 100 region-specific clones from human chromosome 3 in Bornean and Sumatran orangutans, siamang gibbon, and Old and New World monkeys allowed us to reconstruct ancestral simian and hominoid chromosomes. A single paracentric inversion derives chromosome 1 of the Old World monkey Presbytis cristata from the simian ancestor. In the New World monkey Callithrix geoffroyi and siamang, the ancestor diverged on multiple chromosomes, through utilizing different breakpoints. One shared and two independent inversions derive Bornean orangutan 2 and human 3, implying that neither Bornean orangutans nor humans have conserved the ancestral chromosome form. The inversions, fissions, and translocations in the five species analyzed involve at least 14 different evolutionary breakpoints along the entire length of human 3; however, particular regions appear to be more susceptible to chromosome reshuffling. The ancestral pericentromeric region has promoted both large-scale and micro-rearrangements. Small segments homologous to human 3q11.2 and 3q21.2 were repositioned intrachromosomally independent of the surrounding markers in the orangutan lineage. Breakage and rearrangement of the human 3p12. 3 region were associated with extensive intragenomic duplications at multiple orangutan and gibbon subtelomeric sites. We propose that new chromosomes and genomes arise through large-scale rearrangements of evolutionarily conserved genomic building blocks and additional duplication, amplification, and/or repositioning of inherently unstable smaller DNA segments contained within them.
dc.identifier.issn0888-7543
dc.identifier.urihttp://hdl.handle.net/1885/88704
dc.publisherAcademic Press
dc.sourceGenomics
dc.subjectKeywords: article; biodiversity; chromosome 1; chromosome 12; chromosome 21; chromosome 3; chromosome 3p; chromosome 3q; controlled study; gene amplification; gene duplication; gene translocation; genomics; hominid; human; molecular evolution; monkey; orang utan; p Comparative FISH; Conservation of chromosomal synteny; Evolutionary chromosome breakpoint; Human chromosome evolution; Intragenomic duplication; Primate genomics
dc.titlePlasticity of human chromosome 3 during primate evolution
dc.typeJournal article
local.bibliographicCitation.lastpage202
local.bibliographicCitation.startpage193
local.contributor.affiliationTsend-Ayush, Enkhjargal, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGruetzner, Frank, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationYue, Ying, Johannes Gutenberg University of Mainz
local.contributor.affiliationGrossmann, Barbel, Johannes Gutenberg University of Mainz
local.contributor.affiliationHansel, Ulrike, Max Planck Institute for Molecular Genetics
local.contributor.affiliationSudbrak, Ralf, Max Planck Institute for Molecular Genetics
local.contributor.affiliationHaaf, Thomas, Johannes Gutenberg University of Mainz
local.contributor.authoremailrepository.admin@anu.edu.au
local.contributor.authoruidTsend-Ayush, Enkhjargal, u4047128
local.contributor.authoruidGruetzner, Frank, u4034815
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor060401 - Anthropological Genetics
local.identifier.ariespublicationMigratedxPub18492
local.identifier.citationvolume83
local.identifier.doi10.1016/j.ygeno.2003.08.012
local.identifier.scopusID2-s2.0-0347359153
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

Downloads

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
01_Tsend-Ayush_Plasticity_of_human_chromosome_2004.pdf
Size:
475.14 KB
Format:
Adobe Portable Document Format
Back to topicon-arrow-up-solid
 
APRU
IARU
 
edX
Group of Eight Member

Acknowledgement of Country

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.


Contact ANUCopyrightDisclaimerPrivacyFreedom of Information

+61 2 6125 5111 The Australian National University, Canberra

TEQSA Provider ID: PRV12002 (Australian University) CRICOS Provider Code: 00120C ABN: 52 234 063 906