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Synthesis of (±)-panduratin A and related natural products using the high pressure Diels-Alder reaction

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Date

2013

Authors

Pasfield, Luke
de la Cruz, Laura
Ho, Junming
Coote, Michelle
McLeod, Malcolm
Otting, Gottfried

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley-VCH Verlag GMBH

Abstract

Under pressure: PanduratinA (1) has been synthesized in six steps including a high pressure Diels-Alder reaction. This divergent sequence also allowed the synthesis of 4-hydroxypanduratinA, panduratinH, panduratinI, nicolaioidesinB, and 2-hydroxyisopanduratinA. The binding of panduratinA to the dengue virus NS2B-NS3 protease was investigated by NMR spectroscopy.

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Keywords

Citation

URI

http://hdl.handle.net/1885/19068

Collections

ANU Research Publications

Source

Asian Journal of Organic Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1002/ajoc.201200171

Restricted until

2037-12-31

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01_Pasfield_Synthesis_of_(±)-panduratin_A_2013.pdf (274.13 KB)

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