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Review of Mutarotase in 'Metabolic Subculture' and Analytical Biochemistry: Prelude to 19F NMR Studies of its Substrate Specificity and Mechanism

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dc.contributor.authorShishmarev, Dmitry
dc.contributor.authorQuiquempoix, Lucas
dc.contributor.authorFontenelle, Clement Q
dc.contributor.authorLinclau, Bruno
dc.contributor.authorKuchel, Philip William
dc.date.accessioned2021-01-12T03:42:48Z
dc.date.issued2020
dc.date.updated2020-11-02T04:17:23Z
dc.description.abstractThis is the first paper in a sequential pair devoted to the enzyme mutarotase (aldose 1-epimerase; EC 5.1.3.3). Here, the broader context of the physiological role of mutarotase, among those enzymes considered to be part of ‘metabolic structure’, is reviewed. We also summarise the current knowledge about the molecular mechanism and substrate specificity of the enzyme, which is considered in the context of the binding of fluorinated glucose analogues to the enzyme’s active site. This was done as a prelude to our experimental studies of the anomerisation of fluorinated sugars by mutarotase that are described in the following paper.en_AU
dc.description.sponsorshipThe work was funded by a grant from the Leverhulme Trust (RPG-2015- 211) and from the Australian Research Council (DP140102596).en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0004-9425en_AU
dc.identifier.urihttp://hdl.handle.net/1885/219293
dc.language.isoen_AUen_AU
dc.publisherCSIRO Publishingen_AU
dc.relationhttp://purl.org/au-research/grants/arc/DP140102596en_AU
dc.rightsJournal compilation © CSIRO 2020en_AU
dc.sourceAustralian Journal of Chemistryen_AU
dc.titleReview of Mutarotase in 'Metabolic Subculture' and Analytical Biochemistry: Prelude to 19F NMR Studies of its Substrate Specificity and Mechanismen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue3en_AU
local.bibliographicCitation.lastpage116en_AU
local.bibliographicCitation.startpage112en_AU
local.contributor.affiliationShishmarev, Dmitry, College of Health and Medicine, ANUen_AU
local.contributor.affiliationQuiquempoix, Lucas, University of Southamptonen_AU
local.contributor.affiliationFontenelle, Clement Q, University of Southamptonen_AU
local.contributor.affiliationLinclau, Bruno, University of Southamptonen_AU
local.contributor.affiliationKuchel, Philip William, University of Sydneyen_AU
local.contributor.authoruidShishmarev, Dmitry, u4810560en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor060101 - Analytical Biochemistryen_AU
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciencesen_AU
local.identifier.ariespublicationa383154xPUB11468en_AU
local.identifier.citationvolume73en_AU
local.identifier.doi10.1071/CH19397en_AU
local.publisher.urlhttp://www.publish.csiro.au/nid/51.htmen_AU
local.type.statusPublished Versionen_AU

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