Binding inhibitors of the bacterial sliding clamp by design

Date

2011

Authors

Wijffels, Gene
Johnson, Wynona M
Oakley, Aaron
Turner, Kathleen
Epa, V Chandana
Briscoe, Susan J
Polley, Mitchell
Liepa, Andris J
Hofmann, Albert
Buchardt, Jens

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

The bacterial replisome is a target for the development of new antibiotics to combat drug resistant strains. The β2 sliding clamp is an essential component of the replicative machinery, providing a platform for recruitment and function of other replisoma

Description

Keywords

Keywords: bacterial DNA; bacterial sliding clamp; biphenyl; biphenyl oxime; replisome; unclassified drug; article; binding affinity; binding site; carboxy terminal sequence; crystal structure; DNA binding motif; DNA repair; DNA replication; pharmacophore; protein m

Citation

Source

Journal of Medicinal Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/jm2004333

Restricted until

2037-12-31