Binding inhibitors of the bacterial sliding clamp by design

Wijffels, Gene; Johnson, Wynona M; Oakley, Aaron; Turner, Kathleen; Epa, V Chandana; Briscoe, Susan J; Polley, Mitchell; Liepa, Andris J; Hofmann, Albert; Buchardt, Jens; Christensen, Caspar; Prosselkov, Pavel; Dalrymple, Brian Paul; Alewood, Paul F; Jennings, Phil A; Dixon, Nicholas; Winkler, David A

Binding inhibitors of the bacterial sliding clamp by design

Date

2011

Authors

Wijffels, Gene

Johnson, Wynona M

Oakley, Aaron

Turner, Kathleen

Epa, V Chandana

Briscoe, Susan J

Polley, Mitchell

Liepa, Andris J

Hofmann, Albert

Buchardt, Jens

Publisher

American Chemical Society

Abstract

The bacterial replisome is a target for the development of new antibiotics to combat drug resistant strains. The β2 sliding clamp is an essential component of the replicative machinery, providing a platform for recruitment and function of other replisoma