Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Binding inhibitors of the bacterial sliding clamp by design

Thumbnail Image

Date

2011

Authors

Wijffels, Gene
Johnson, Wynona M
Oakley, Aaron
Turner, Kathleen
Epa, V Chandana
Briscoe, Susan J
Polley, Mitchell
Liepa, Andris J
Hofmann, Albert
Buchardt, Jens

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

The bacterial replisome is a target for the development of new antibiotics to combat drug resistant strains. The β2 sliding clamp is an essential component of the replicative machinery, providing a platform for recruitment and function of other replisoma

Description

Keywords

Keywords: bacterial DNA; bacterial sliding clamp; biphenyl; biphenyl oxime; replisome; unclassified drug; article; binding affinity; binding site; carboxy terminal sequence; crystal structure; DNA binding motif; DNA repair; DNA replication; pharmacophore; protein m

Citation

URI

http://hdl.handle.net/1885/59270

Collections

ANU Research Publications

Source

Journal of Medicinal Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/jm2004333

Restricted until

2037-12-31

Downloads

File
Description
01_Wijffels_Binding_inhibitors_of_the_2011.pdf (2.32 MB)

DSpace software copyright © 2002-2026 LYRASIS

abcd