The role of ring D in the antitumor antibiotic streptonigrin: metal complexation, DNA binding and topoisomerase inhibition by ABC ring analogues of streptonigrin
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Anderberg, Pia I
Harding, Margaret
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Cognizant Communication Corporation
Abstract
The interaction of 7-amino-2-(6′-carboxy-2′-pyridyl)-6-methoxy-5,8-quinolinedione, an ABC ring analogue of the antitumour antibiotic streptonigrin, with zinc(II), oligonucleotides and DNA in the presence of zinc(II), and on the relaxation of DNA by to
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Anti-Cancer Drug Design