Genetic repositories for the study of major psychiatric conditions: What do we know about ethnic minorities' genetic vulnerability

Date

2010

Authors

Oquendo, M.A.
Canino, G.
Lehner, T
Licinio, Julio

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Publishing Group

Abstract

In spite of considerable efforts, no genes of major effect have been found across an entire diagnostic category in psychiatry. Possible reasons for this may include difficulties in defining the phenotype, the complex relationship between genotype and gene expression and population stratification. This last problem has often been managed by restricting genetic sampling to only one ethnic group. An unintended consequence of using this strategy is that the major repositories of genetic material for the study of psychiatric conditions in the United States suffer from a paucity of genetic samples from non-Caucasian groups. Thus, these groups are being relatively understudied in terms of the genetic antecedents to psychiatric disease. The authors provide solutions including the need to augment the representation of African-American, Latino and Asian-Americans among research participants; a more nuanced approach to identify ancestry; and the development of analytic and genetic strategies to handle the issue of ethnic heterogeneity in samples.

Description

Keywords

Keywords: African American; Asian American; ethnic group; gene expression; genetic analysis; genetic heterogeneity; genetic susceptibility; genotype; Hispanic; human; mental disease; phenotype; priority journal; race difference; review; Ethnic Groups; Genetic Heter diversity; DNA; race

Citation

Source

Molecular Psychiatry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1038/mp.2010.11

Restricted until

2037-12-31