Pick Bodies in a Family with Presenilin-1 Alzheimer's Disease
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Date
Authors
Halliday, Glenda M
Song, Yun Ju C
Lepar, Gila
Brooks, William S
Kwok, John B
Kersaitis, Cindy
Gregory, Gillian
Shepherd, Claire E
Rahimi, Ahmed (Farid)
Schofield, Peter
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Volume Title
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Wiley-Liss Inc
Abstract
Presenilin-1 (PS-1) mutations can cause Pick's disease without evidence of Alzheimer's disease (AD). We describe a family with a PS-1 M146L mutation and both Pick bodies and AD. Sarkosyl-insoluble hyperphosphorylated tau showed three bands consistent with AD, although dephosphorylation showed primarily three-repeat isoforms. M146L mutant PS-1 may predispose to both Pick's disease and AD by affecting multiple intracellular pathways involving tau phosphorylation and amyloid metabolism.
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Source
Annals of Neurology
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Restricted until
2037-12-31