Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses

Simple item page
dc.contributor.authorMacLennan, Ian C M
dc.contributor.authorGarcia De Vinuesa, Maria Carola
dc.date.accessioned2015-12-13T23:39:53Z
dc.date.issued2002
dc.date.updated2015-12-12T09:27:04Z
dc.description.abstractThe first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.
dc.identifier.issn1074-7613
dc.identifier.urihttp://hdl.handle.net/1885/94228
dc.publisherCell Press
dc.sourceImmunity
dc.subjectKeywords: APRIL protein; autoantibody; protein; protein BAFF; unclassified drug; amino acid sequence; antibody production; antibody response; B lymphocyte; cell activity; cell maturation; cell survival; dendrite; priority journal; regulatory mechanism; short survey
dc.titleDendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses
dc.typeJournal article
local.bibliographicCitation.lastpage238
local.bibliographicCitation.startpage235
local.contributor.affiliationMacLennan, Ian C M, University of Birmingham
local.contributor.affiliationGarcia De Vinuesa, Maria Carola, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidGarcia De Vinuesa, Maria Carola, u4164556
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationMigratedxPub23763
local.identifier.citationvolume17
local.identifier.doi10.1016/S1074-7613(02)00398-9
local.identifier.scopusID2-s2.0-0036753722
local.type.statusPublished Version

Downloads

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
01_MacLennan_Dendritic_cells,_BAFF,_and_2002.pdf
Size:
140.13 KB
Format:
Adobe Portable Document Format
Download

Collections

ANU Research Publications

DSpace software copyright © 2002-2026 LYRASIS

abcd