Chelating DTPA amphiphiles: Ion-tunable self-assembly structures and gadolinium complexes

dc.contributor.authorMoghaddam, Minoo
dc.contributor.authorDe Campo, Liliana
dc.contributor.authorKirby, N
dc.contributor.authorDrummond, Calum
dc.date.accessioned2015-12-10T23:22:34Z
dc.date.issued2012
dc.date.updated2016-02-24T08:44:20Z
dc.description.abstractA series of chelating amphiphiles and their gadolinium (Gd(iii)) metal complexes have been synthesized and studied with respect to their neat and lyotropic liquid crystalline phase behavior. These amphiphiles have the ability to form ion-tunable self-assembly nanostructures and their associated Gd III complexes have potential as magnetic resonance imaging (MRI) contrast enhancement agents. The amphiphiles are composed of diethylenetriaminepentaacetic acid (DTPA) chelates conjugated to one or two oleyl chain(s) (DTPA-MO and DTPA-BO), or isoprenoid-type chain(s) of phytanyl (DTPA-MP and DTPA-BP). The thermal phase behavior of the neat amphiphiles was examined by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and cross polarizing optical microscopy (POM). Self-assembly of neat amphiphiles and their associated Gd complexes, as well as their lyotropic phase behavior in water and sodium acetate solutions of different ionic strengths, were examined by POM and small and wide angle X-ray scattering (SWAXS). All neat amphiphiles exhibited lamellar structures. The non-complexed amphiphiles showed a variety of lyotropic phases depending on the number and nature of the hydrophobic chain in addition to the ionic state of the hydration. Upon hydration with increased Na-acetate concentration and the subtle changes in the effective headgroup size, the interfacial curvature of the amphiphile increased, altering the lyotropic liquid crystalline structures towards higher order mesophases such as the gyroid (Ia3d) bicontinuous cubic phase. The chelation of Gd with the DTPA amphiphiles resulted in lamellar crystalline structures for all the neat amphiphiles. Upon hydration with water, the Gd-complexed mono-conjugates formed micellar or vesicular self-assemblies, whilst the bis-conjugates transformed only partially into lyotropic liquid crystalline mesophases.
dc.identifier.issn1463-9076
dc.identifier.urihttp://hdl.handle.net/1885/66575
dc.publisherRoyal Society of Chemistry
dc.sourcePhysical Chemistry Chemical Physics
dc.subjectKeywords: chelating agent; contrast medium; coordination compound; gadolinium; nanomaterial; pentetic acid; article; chemical phenomena; chemistry; crystallization; nuclear magnetic resonance imaging; small angle scattering; X ray diffraction; Chelating Agents; Con
dc.titleChelating DTPA amphiphiles: Ion-tunable self-assembly structures and gadolinium complexes
dc.typeJournal article
local.bibliographicCitation.issue37
local.bibliographicCitation.lastpage12862
local.bibliographicCitation.startpage12854
local.contributor.affiliationMoghaddam, Minoo, CSIRO
local.contributor.affiliationDe Campo, Liliana, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationKirby, N, Australian Synchrotron
local.contributor.affiliationDrummond, Calum, CSIRO
local.contributor.authoremailu4334138@anu.edu.au
local.contributor.authoruidDe Campo, Liliana, u4334138
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor020400 - CONDENSED MATTER PHYSICS
local.identifier.ariespublicationf5625xPUB1308
local.identifier.citationvolume14
local.identifier.doi10.1039/c2cp41300k
local.identifier.scopusID2-s2.0-84865734261
local.identifier.thomsonID000308101100020
local.identifier.uidSubmittedByf5625
local.type.statusPublished Version

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