Association of smoking and personality with a polymorphism of the dopamine transporter gene: results from a community survey
Date
2000
Authors
Jorm, Anthony F
Henderson, A Scott
Jacomb, Trish
Christensen, Helen
Korten, Ailsa
Tan, Susan (Xiaoyun)
Easteal, Simon
Rodgers, Bryan
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John Wiley & Sons Inc
Abstract
In studies that used mixed volunteer samples, Letman et al. [1999: Health Psychol 18:14-20] and Sabol et al. [1999: Health Psychol 18:7-13] reported on an association of smoking with a polymorphism of the dopamine transporter gene. We attempted to replicate this association in a nonvolunteer community sample of 861 Caucasians. No associations were found with either smoking initiation or smoking cessation. Sabol et al. [1999] also reported on an association of the dopamine transporter polymorphism with the personality trait of novelty seeking. However, we failed to find any associations with a range of personality traits, including a scale of fun seeking that correlates with novelty seeking. These negative findings suggest that either the original associations are not replicable or that any association is very small. (C) 2000 Wiley-Liss, Inc.
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Keywords
Keywords: dopamine transporter; article; Caucasian; community; genetic association; genetic polymorphism; genotype; human; normal human; personality; priority journal; smoking; smoking cessation; Adult; Analysis of Variance; Australia; Carrier Proteins; Chi-Square Association study; Dopamine transporter gene; Novelty seeking; Personality; Smoking
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Source
American Journal of Medical Genetics, Part A
Type
Journal article
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2037-12-31
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