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Nitric Oxide Donation Lowers Blood Pressure in Adrenocorticotrophic Hormone-Induced Hypertensive Rats

Date

Authors

Andrews, Miles

Schyvens, Chris

Zhang, Yi

McKenzie, Katja

Whitworth, Judith

Publisher

Informa Healthcare

Abstract

Adrenocorticotrophic hormone (ACTH) elevates systolic blood pressure (SBP) and lowers plasma reactive nitrogen intermediates in rats. We assessed the ability of NO donation from isosorbide dinitrate (ISDN) to prevent or reverse the hypertension caused by

Keywords

Keywords: corticotropin; drinking water; glucocorticoid; isosorbide dinitrate; nitrate; nitric oxide; adrenal cortex; animal model; article; blood pressure; blood pressure measurement; controlled study; drug effect; hormonal regulation; hypertension; male; nonhuman Adrenocorticotrophic hormone; Glucocorticoids; Hypertension; Isosorbide dinitrate; Nitric oxide

URI

http://hdl.handle.net/1885/81022

Collections

ANU Research Publications

Source

Clinical and Experimental Hypertension

Type

Journal article

DOI

10.1081/CEH-200031824