Comparison and visualisation of agreement for paired lists of rankings

dc.contributor.authorDonald, Margaret R
dc.contributor.authorWilson, Susan
dc.date.accessioned2021-05-26T03:53:32Z
dc.date.available2021-05-26T03:53:32Z
dc.date.issued2017
dc.date.updated2020-11-23T10:20:38Z
dc.description.abstractOutput from analysis of a high-throughput ‘omics’ experiment very often is a ranked list. One commonly encountered example is a ranked list of differentially expressed genes from a gene expression experiment, with a length of many hundreds of genes. There are numerous situations where interest is in the comparison of outputs following, say, two (or more) different experiments, or of different approaches to the analysis that produce different ranked lists. Rather than considering exact agreement between the rankings, following others, we consider two ranked lists to be in agreement if the rankings differ by some fixed distance. Generally only a relatively small subset of the k top-ranked items will be in agreement. So the aim is to find the point k at which the probability of agreement in rankings changes from being greater than 0.5 to being less than 0.5. We use penalized splines and a Bayesian logit model, to give a nonparametric smooth to the sequence of agreements, as well as pointwise credible intervals for the probability of agreement. Our approach produces a point estimate and a credible interval for k. R code is provided. The method is applied to rankings of genes from breast cancer microarray experiments.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1544-6115en_AU
dc.identifier.urihttp://hdl.handle.net/1885/233805
dc.language.isoen_AUen_AU
dc.provenancehttps://v2.sherpa.ac.uk/id/publication/19269..."The Published Version can be archived in a Non-Commercial Institutional Repository. 12 months embargo" from SHERPA/RoMEO site (as at 26/05/2021).en_AU
dc.publisherBerkeley Electronic Pressen_AU
dc.rights© 2017 The Author(s)en_AU
dc.sourceStatistical Applications in Genetics and Molecular Biologyen_AU
dc.titleComparison and visualisation of agreement for paired lists of rankingsen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue1en_AU
local.bibliographicCitation.lastpage45en_AU
local.bibliographicCitation.startpage31en_AU
local.contributor.affiliationDonald, Margaret R, University of New South Walesen_AU
local.contributor.affiliationWilson, Susan, College of Science, ANUen_AU
local.contributor.authoremailu7401449@anu.edu.auen_AU
local.contributor.authoruidWilson, Susan, u7401449en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor010401 - Applied Statisticsen_AU
local.identifier.absfor111203 - Cancer Geneticsen_AU
local.identifier.absseo920110 - Inherited Diseases (incl. Gene Therapy)en_AU
local.identifier.absseo970101 - Expanding Knowledge in the Mathematical Sciencesen_AU
local.identifier.ariespublicationu4485658xPUB950en_AU
local.identifier.citationvolume16en_AU
local.identifier.doi10.1515/sagmb-2016-0036en_AU
local.identifier.scopusID2-s2.0-85016051785
local.identifier.thomsonID000396007900003
local.identifier.uidSubmittedByu4485658en_AU
local.publisher.urlhttps://www.degruyter.com/view/j/sagmben_AU
local.type.statusPublished Versionen_AU

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