Associations between plasma antioxidants and hypertension in a community based sample aged 60- 64 years

Date

2005

Authors

Parslow, Ruth
Sachdev, Perminder Singh
Salonikas, Chris
Lux, Ora
Jorm, Anthony F
Naidoo, Daya

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Publishing Group

Abstract

It has been suggested that increased oxidative stress may be both a cause as well as a consequence of hypertension. In vivo oxidation of low-density lipoproteins by oxygen-free radicals may increase hypertension-related atherogenesis, and antioxidants may be beneficial in this regard. Previous findings concerning associations between serum measures of antioxidants; and hypertension have however been inconsistent. Plasma levels of β-carotene, Vitamin A, E, uric acid, homocysteine and total antioxidant capacity, as well as two markers of oxidative stress, malondialdehyde (MDA) and protein carbonyls, were measured in morning fasting blood samples provided by 415 Australians aged 60-64 years, selected randomly from the community. Participants also provided information on sociodemographic attributes, mental and physical health, and provided two measures of resting blood pressure, allowing a diagnosis of definite or borderline hypertension. Those with hypertension had lower levels of β-carotene and higher levels of uric acid and MDA compared to normotensive participants. The last two of these associations persisted when the analyses controlled for lifestyle and health factors. The findings from this study offer limited support for the proposition that lower antioxidant status and higher oxidative stress are associated with hypertension, and suggest the need for longitudinal studies to examine causality and intervention studies to determine the benefit of antioxidants in this group.

Description

Keywords

Keywords: alpha tocopherol; antioxidant; beta carotene; carbonyl derivative; homocysteine; low density lipoprotein; malonaldehyde; oxygen radical; retinol; uric acid; adult; article; atherogenesis; Australia; blood pressure measurement; blood sampling; community; c Antioxidants; Epidemiology; Older adults

Citation

Source

Journal of Human Hypertension

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1038/sj.jhh.1001809

Restricted until

2037-12-31