Amphiphilic polymer coated nanodiamonds: A promising platform to deliver azonafide

dc.contributor.authorLai, H.
dc.contributor.authorLu, Mingxia
dc.contributor.authorLalevée, Jacques
dc.contributor.authorStenzel, Martina H.
dc.contributor.authorXiao, Pu
dc.date.accessioned2021-06-15T00:34:34Z
dc.date.issued2019-03-14
dc.description.abstractNanodiamonds (NDs) are attracting increasing attention as drug delivery systems due to their outstanding mechanical and optical properties as well as excellent biocompatibility. However, the strong tendency to agglomerate limits their use in biological medium, especially when adsorbed hydrophobic compounds. Polymer coating is a convenient approach to enhance the colloidal stability and place therapeutic drugs. Here, we report an epoxy containing amphiphilic block copolymer poly(n-butyl methacrylate-co-polyglycidol methacrylate-block-poly(oligoethylene glycol methyl ether methacrylate)) (PBA-co-PGA-b-POEGMEMA) for coating NDs. The resultant polymer coating significantly reduced the particle size and enhanced the colloidal stability. The inner hydrophobic block was exploited to encapsulate hydrophobic anticancer drug-azonafide. The cytotoxicity of the azonafide-loaded NDs was evaluated by 2D and 3D models. Although azonafide encapsulation displayed higher IC50 than free azonafide in the 2D breast tumour cell culture model, the former showed accelerated cytotoxicity than free azonafide in the 3D breast multicellular tumour spheroids. The results indicate the amphiphilic polymer coated NDs could be a promising carrier for azonafide due to the facile synthesis protocol, the potential to reduce side effects and the enhanced toxicity.en_AU
dc.description.sponsorshipP. X. acknowledges funding from the Australian Research Council’s Discovery Early Career Researcher Award (DE140100318) and Future Fellowship (FT170100301).en_AU
dc.identifier.issn1759-9954en_AU
dc.identifier.urihttp://hdl.handle.net/1885/237334
dc.publisherRoyal Society of Chemistryen_AU
dc.relationhttp://purl.org/au-research/grants/arc/FT170100301en_AU
dc.relationhttp://purl.org/au-research/grants/arc/DE140100318en_AU
dc.rights© 2019 The Royal Society of Chemistryen_AU
dc.sourcePolymer Chemistryen_AU
dc.titleAmphiphilic polymer coated nanodiamonds: A promising platform to deliver azonafideen_AU
dc.typeJournal articleen_AU
dcterms.dateAccepted2019-03-04
local.bibliographicCitation.issue15en_AU
local.bibliographicCitation.lastpage1911en_AU
local.bibliographicCitation.startpage1904en_AU
local.contributor.affiliationLai, H., University of New South Walesen_AU
local.contributor.affiliationLu, Mingxia, University of New South Walesen_AU
local.contributor.affiliationLalevée, Jacques, Université de Haute-Alsaceen_AU
local.contributor.affiliationStenzel, Martina H., University of New South Walesen_AU
local.contributor.affiliationXiao, Pu, College of Science, ANUen_AU
local.contributor.authoremailu1053596@anu.edu.auen_AU
local.contributor.authoruidXiao, Pu, u1053596en_AU
local.description.embargo2099-12-31
local.description.notesAdded manually as didn't import from ARIESen_AU
local.identifier.absfor030306 - Synthesis of Materialsen_AU
local.identifier.absfor030399 - Macromolecular and Materials Chemistry not elsewhere classifieden_AU
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciencesen_AU
local.identifier.ariespublicationu3102795xPUB1472en_AU
local.identifier.citationvolume10en_AU
local.identifier.doi10.1039/c9py00055ken_AU
local.identifier.uidSubmittedByu5031974en_AU
local.publisher.urlhttps://pubs.rsc.org/en_AU
local.type.statusPublished Versionen_AU

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