Organic Osmolyte Channels: A Comparative View

Date

2000

Authors

Junankar, Pauline
Kirk, Kiaran

Journal Title

Journal ISSN

Volume Title

Publisher

S Karger AG

Abstract

Cells respond to osmotic swelling by releasing inorganic ions and small organic molecules (organic osmolytes). In many cell-types, osmotic swelling results in the activation of an outwardly-rectifying anion-selective current. The channel underlying this current has a significant permeability to a number of organic osmolytes and may play a role in the hypoosmotically-activated efflux of these compounds. However, there is also evidence that the volume-regulatory efflux of organic osmolytes involves other pathways which may be selective for neutral osmolytes over anions.

Description

Keywords

Keywords: anion channel; animal cell; cell membrane transport; cell swelling; cell type; comparative study; electrophysiology; eukaryotic cell; nonhuman; osmolarity; osmoregulation; osmotic stress; priority journal; review; volume sensitive organic osmolyte and ani Anion channel; Organic osmolyte; Osmotic swelling; RVD; Taurine; VSOAC

Citation

Source

Cellular Physiology and Biochemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1159/000016368

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