From the black widow spider to human behavior: Latrophilins, a relatively unknown class of G protein-coupled receptors, are implicated in psychiatric disorders

Date

2011

Authors

Martinez, Ariel F.
Muenke, Maximilian
Arcos-Burgos, Mauricio

Journal Title

Journal ISSN

Volume Title

Publisher

John Wiley & Sons Inc

Abstract

The findings of a recent study associate LPHN3, a member of the latrophilin family, with an increased risk of developing attention deficit/hyperactivity disorder (ADHD), the most common psychiatric disorder in childhood and adolescence. Latrophilins comprise a new family of G protein-coupled receptors of unknown native physiological function that mediate the neurotoxic effects of α-latrotoxin, a potent toxin found in black widow spider venom. This receptor-toxin interaction has helped to elucidate the mechanistic aspects of neurotransmitter and hormone release in vertebrates. Such unprecedented discovery points to a new direction in the assessment of ADHD and suggest that further study of this receptor family may provide novel insights into the etiology and treatment of ADHD and other related psychiatric conditions.

Description

Keywords

Keywords: 4,4' isopropylidenediphenol; alcohol; alpha latrotoxin; chlorine; doxorubicin; ethinylestradiol; fluorouracil; G protein coupled receptor; latrophilin; methotrexate; mustard gas; neurotransmitter; ozone; palm oil; paracetamol; paraquat; unclassified drug; a-latrotoxin; ADHD; G protein-coupled receptor; Latrophilin; LPHN3

Citation

Source

American Journal of Medical Genetics, Part B: Neuropsychiatric

Type

Journal article

Book Title

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Restricted until

2037-12-31