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Protein interactions involving the gamma2 large cytoplasmic loop of GABA A receptors modulate conductance

Date

Authors

Everitt, Andrea

Seymour, Victoria

Curmi, John

Laver, Derek Rowland

Gage, Peter

Tierney, Mary (Louise)

Publisher

Federation of American Societies for Experimental Biology

Abstract

Native GABAA channels display a single-channel conductance ranging between ∼10 and 90 pS. Diazepam increases the conductance of some of these native channels but never those of recombinant receptors, unless they are coexpressed with GABARAP. This traffi

Keywords

Keywords: 4 aminobutyric acid A receptor; diazepam; ion channel; animal cell; article; brain; channel gating; conductance; controlled study; cytoplasm; ion transport; molecular mimicry; mouse; neuromodulation; neurotransmission; newborn; nonhuman; priority journal; Competitor peptide; Diazepam; MA helix; Single-channel conductance

URI

http://hdl.handle.net/1885/27896

Collections

ANU Research Publications

Source

FASEB Journal

Type

Journal article

DOI

10.1096/fj.09-137042

Restricted until

2037-12-31

Downloads

File

Description

01_Everitt_Protein_interactions_involving_2009.pdf (404.07 KB)