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Identification and Characterization of gamma-Glutamylamine Cyclotransferase, an Enzyme Responsible for gamma-Glutamyl-epsilon-lysine Catabolism

Date

Authors

Oakley, Aaron

Coggan, Marjorie

Board, Philip

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

γ-Glutamylamine cyclotransferase (GGACT) is an enzyme that converts γ-glutamylamines to free amines and 5-oxoproline. GGACT shows high activity toward γ-glutamyl-ε-lysine, derived from the breakdown of fibrin and other proteins cross-linked by transgl

Keywords

Keywords: Active site; Different substrates; Enzymatic activities; Free amines; High activity; Sequence identity; Three-dimensional structure; Transglutaminases; Amination; Amino acids; Catalysts; Enzymes; Organic acids; Plants (botany); Enzyme activity; 6 (gamma g

URI

http://hdl.handle.net/1885/17780

Collections

ANU Research Publications

Source

Journal of Biological Chemistry

Type

Journal article

DOI

10.1074/jbc.M109.082099

Restricted until

2037-12-31

Downloads

File

Description

01_Oakley_Identification_and_2010.pdf (2.03 MB)