The Putative Role of Natural Killer Cells in Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma

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dc.contributor.authorHassona, Mona M
dc.contributor.authorRadwan, Enas M
dc.contributor.authorAbdelsameea, Eman
dc.contributor.authorESTAPHAN, Suzanne
dc.contributor.authorAbd Elrhman, Heba E
dc.contributor.authorAbdel-Samiee, Mohamed
dc.contributor.authorNaguib, Mary
dc.date.accessioned2023-02-21T01:27:20Z
dc.date.issued2021
dc.date.updated2021-12-12T08:13:25Z
dc.description.abstractBackground: Natural Killer (NK) cells have crucial roles in immune responses against malignant transformation including hepatocellular carcinoma (HCC). The NKG2D receptor has a critical role in the NK recognition of target cells. Aim: We assessed NKG2D receptor expression as a diagnostic biomarker for HCC detection and progression in Egyptian patients with hepatitis C virus (HCV)-related HCC. Methods: We classified 81 patients into three groups: chronic hepatitis (21), cirrhotic (30) and HCC (30) patients, with 36 individuals enrolled to the control group. We analyzed NK levels in peripheral blood and NKG2D receptor expression in NK cells using flow cytometry. Results: We observed a significant decrease in NKG2D (CD314) expression on circulating NK cells and frequency of NK cells expressing NKG2D (CD314) in HCC patients. Also, in patients, larger foci lesions significantly correlated with decreased NK cell numbers. Multiple foci numbers and patients with a Child score C significantly correlated with decreased circulating NK cells expressing NKG2D and decreased NKG2D expression. Conclusion: The percentage of NK cells in peripheral blood and NKG2D receptor expression could function as potential biomarkers for HCC detection and progression.en_AU
dc.description.sponsorshipThe study was funded by the Research Unit of Menoufia Universityen_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2476-762Xen_AU
dc.identifier.urihttp://hdl.handle.net/1885/285394
dc.language.isoen_AUen_AU
dc.publisherAsia Pacific Organization for Cancer Preventionen_AU
dc.rights© 2021 The authorsen_AU
dc.sourceAsia Pacific Journal of Cancer Preventionen_AU
dc.subjectHepatocellular carcinomaen_AU
dc.subjecthepatitis C Virusen_AU
dc.subjectnatural killer cellsen_AU
dc.subjectNKG2D receptoren_AU
dc.titleThe Putative Role of Natural Killer Cells in Patients with Hepatitis C Virus-Related Hepatocellular Carcinomaen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue8en_AU
local.bibliographicCitation.lastpage2567en_AU
local.bibliographicCitation.startpage2559en_AU
local.contributor.affiliationHassona, Mona M, Department of Clinical and Chemical Pathology, National Liver Institute, Menoufia University, Shebeen El-Kom, Egypten_AU
local.contributor.affiliationRadwan, Enas M, Department of Clinical Pathology, National Cancer Institute, Cairo Universityen_AU
local.contributor.affiliationAbdelsameea, Eman, Hepatology and Gastroenterology, National Liver Institute, Clinical Pathology, Menoufia University,en_AU
local.contributor.affiliationEstaphan, Suzanne, College of Health and Medicine, ANUen_AU
local.contributor.affiliationAbd Elrhman, Heba E, Department of Clinical Pathology, Faculty of Medicine, Zagazig Universityen_AU
local.contributor.affiliationAbdel-Samiee, Mohamed, Hepatology and Gastroenterology, National Liver Institute, Clinical Pathology, Menoufia University, Shebeen El-Kom, Egypten_AU
local.contributor.affiliationNaguib, Mary, Clinical Pathology Department, National Liver Institute, Menoufia University, Egypten_AU
local.contributor.authoremailu1079793@anu.edu.auen_AU
local.contributor.authoruidEstaphan, Suzanne, u1079793en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor320409 - Tumour immunologyen_AU
local.identifier.absfor320209 - Gastroenterology and hepatologyen_AU
local.identifier.absfor320102 - Haematologyen_AU
local.identifier.absseo200101 - Diagnosis of human diseases and conditionsen_AU
local.identifier.absseo280103 - Expanding knowledge in the biomedical and clinical sciencesen_AU
local.identifier.ariespublicationu3402575xPUB36en_AU
local.identifier.citationvolume22en_AU
local.identifier.doi10.31557/APJCP.2021.22.8.2559en_AU
local.identifier.uidSubmittedByu3402575en_AU
local.type.statusPublished Versionen_AU

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